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Suez Canal University Medical Journal SCU-MJ

The Official Journal of Faculty of Medicine, Suez Canal University

Founded in 1998

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Current Issue Article, Volume 21, Issue 1, March 2018

Evaluation of Vitamin D Levels in Women with Carpal Tunnel Syndrome

Shaimaa M. Okasha*, Maii A. Abdel-latif, and Marwa Orabi


Background: For decades, the role of vitamin D was limited to the formation and maintenance of bone as well as homeostasis of calcium and phosphate. Vitamin D is a steroid molecule, mainly synthesized in the skin from 7 dehydrocholesterol by ultraviolet irradiation or obtained through the diet. The major circulating metabolite of vitamin D is 25(OH) Vitamin D (25(OH)D), with a half-life of 21–30 days. Serum concentration of 25(OH) D is the most reliable biochemical index of vitamin status. Aim: The goal of the present study was to investigate the relationship between vitamin D levels and carpal tunnel syndrome (CTS) Patients and Methods: This study included 50 female patients with mild to moderate CTS and assessed their serum 25-hydroxyvitamin D levels. We included patients with a diagnosis of CTS based on both the clinical symptoms and positive neurophysiology. Controls (electrophysiological negative symptomatic patients) were evaluated 50 patients matched with sex and age clinically by a rheumatologist. Results: the mean age of patients with CTS symptoms and control group were 49.2 ± 10.6 (range 21–54) and 49.7 ± 10.6 (range 20–55), respectively, with no significant difference between the two groups (p = 0.534). Patients with CTS symptoms had significantly lower 25(OH) D levels compared to controls. There’s significance difference among the CTS patient regarding Boston Carpal Tunnel Questionnaire (BQ). Conclusion: a potential link between vitamin D status and the occurrence of CTS is suggested. Keywords: CTS, Vit. D, Boston Carpal Tunnel Questionnaire