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Suez Canal University Medical Journal SCU-MJ

The Official Journal of Faculty of Medicine, Suez Canal University

Founded in 1998

The first image SCU teaching hospital
  1. SCU teaching hospital
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Current Issue Article, Volume 20, Issue 2, October 2017


Recent advances in genome editing technologies have significantly enhanced making specific changes in the genomes of different types cells. Genetically engineered T cells, or the 'living drugs', is considered a new era in antitumor therapy. Current clinical trials using chimeric antigen receptors (CARs) T cells showed a promising result in patients with some intractable hematological malignancies. In this Review, some of the most recent advances in CAR T cell therapy are mentioned high lightening the use of genome editing in this field. Keywords: CRISPR/Cas9, chimeric antigen receptor, T lymphocytes, gene therapy